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AlumniNewsletterAlumniNewsletter1Spring2013PhysioProgressAlumniNewsletter2013ExecutiveEditorDr.PatriciaBrubakerEditorDr.StephenMatthewsPublishedbytheDepartmentofPhysiologyUniversityofTorontoFacultyofMedicine1KingsCollegeCircleTorontoONM5S1A8Telephone416-978-5077Fax416-978-4940Websitewww.physiology.utoronto.caAlumniNewsletterSpring2013PhysioProgressSeanandGuideGilbertatUhuruPeakonMt.KilimanjaroMatsSundinestablishesmedicalfellowshipsatUofTKarolinskaInsttutet--FormerMapleLeafscaptainsupportsdevelopmentalhealthresearchAuthorLeslieChurchandAprilKemickUofTNewsFormerTorontoMapleLeafscaptainMatsSundinannouncedtodayhewillestablishanelitescienticexchangeprogramintheeldofdevelopmentalhealthbetweentheUniversityofTorontoandKarolinskaInstitutetinStockholmSweden.Sundinsgiftone-thirdof1milliondollarswasannouncedatapressconferenceatUofT.Thegiftwillsupporttwofellowshipsatworld-renownedlabsinTorontoandStockholmwherescientistsareprobinghowmaternalhealthandourearliestlifeexperiencescandeterminesicknesshealthlearningabilityandoverallwell-beingdowntheroad.WeallwantourchildrentogrowuphealthywiththebestopportunitiestolearnandlivefreeofdiseasebuthowdowemakethatpossibleWhatcanwedotogiveourkidsthebestshotatreachingtheirfullpotentialsaidSundin.ByestablishingthisprogramatUofTandKIwerecreatinganOlympictrainingcampforourbrightestyoungmindstoworkwithgloballeadersandanswerthesechallengingquestions.EveryplayerknowswehavearesponsibilitytopassonourskillsandknowledgetothenextgenerationthatshowthesportmovesforwardandscienceaswellSundinadded.Itmeanssomuchtometobeabletosupportthesetwogreatuniversitiesandtheirincredibledrivetondthebreakthroughsthatcanchangeourlives.ThefellowshipsbuildonalongandsuccessfulexchangeprogrambetweenUofTandKarolinskaInstitutetdatingbackto1996.Theexchangeprogramleveragestheverybestresearchthemesfrombothinstitutionstotrainanddevelopstudentsintofuturescienticandmedicalleaderswithaparticularfocusonmaternal-infanthealthneurodevelopmentandregenerativemedicine.FormerTorontoMapleLeafscaptainMatsSundinbeamsasheandDeanCatharineWhitesidedisplaytheUofTFacultyofMedicinesgifofmedicalscrubsbearinghisiconicNo.13.PhotobyDaveChanCelebratng90yearsofinsulinMatsSundinStephenMathews 2AlumniNewsletterSpring2013ItalianChamberofCommerceNatonalBankAward-May242012Dr.IsabellaCaniggiaDept.ofObstetricsandGynaecologyandaPrincipalInvestigatorattheSamuelLunenfeldResearchInstituteofMountSinaiHospitalhasreceivedaNationalBankBusinessExcellenceAward-presentedonbehalfoftheItalianChamberofCommerce-inrecognitionofherfundamentalcontributionstowomensandinfantshealthresearch.ALunenfeldscientistsince1994Dr.Caniggiaisaleadingauthorityonplacentaldevelopmentandpre-eclampsia.LunenfeldresearcherhonouredwithItalianChamberofCommerceNationalBankAwardMay242012TorontoON.IamthrilledtobetherecipientofsuchaprestigiousawardthatrecognizesbothmyworkandmyItalianheritageofwhichIamextremelyproudsaidDr.CaniggiawhowasalsonamedoneoftheTorontoStarslistofPeopletoWatchin2011.ALunenfeldscientistsince1994Dr.Caniggiaisaleadingauthorityonplacentaldevelopmentandpre-eclampsiaaseriouspregnancy-relateddisordercharacterizedbyhighbloodpressureandproteinureaexcessproteinintheurine.Theconditionaffectsmorethan10000pregnantwomeninCanadaeachyearandifleftuntreatedcanbefatalforbothmotherandchild.Isabellaisaremarkablescientistwhobringsenthusiasmandinnovationtoherresearch.HerfamilyiswellknownfortheircontributionstoadvancingmedicaldiscoveriesinItalyandIsabellanowcontinuesthistraditioninheradoptedhomeofCanada.WeareallextremelyproudofherachievementssaidDr.StephenLyeAssociateDirectorofResearchattheLunenfeldandMountSinaiHospitalAuxiliaryChairinWomensandInfantsHealthResearch.Dr.Caniggiahopesthatinthefutureasimplebloodtestwillpredictwhetherapregnantwomanisatriskforpre-eclampsia.Afewyearsagoshelicensedherbiomarkerndingstohelpdevelopadiagnostictoolthatwilldetectandmanagepre-eclampsiainexpectantmothersoverthenextveyears.Potentiallyphysicianswilluseapoint-of-carekittodetectandmeasureincreasedlevelsofthebiomarkerendoglininexpectantmotherswhoareatincreasedriskofpre-eclampsia.Physicianscurrentlytreatingpatientsrelyonsymptomssuchashighbloodpressureandproteininurinetodiscoverwhetherapregnantwomanhasthecondition.Atestthatcoulddiagnosepre-eclampsiaearlyoninpregnancyorpredictwhichwomenareathighriskwouldallowphysicianstocloselymonitorandmanagethesehigh-riskpregnancies.Pre-eclampsiaoccursinaboutsevento10percentofpregnanciesandmaydevelopfrom20weeksgestationoftenleadingtopre-termdeliveryorpoorfetalgrowth.ApartfromCaesareansectionorinductionoflabourthereisnoknowncureandpreviousdrugapproacheshavebeenunsuccessful.Itisthemostcommonanddangerouspregnancy-relatedcomplicationaffectingbothmotherandunbornchild.Readentirearticleathttpresearch.lunenfeld.carssnewspage1940sign_onTableofContentMatsSundinEstablishesMedicalFellowshipsatUofTKarolinskaInsttutet...............................................................1ItalianChamberofCommerceNatonalBankAward....................................................................................................2Celebratng90YearsofInsulinNewBantng-BestExhibitaTrueSliceofHistory.........................................................3PhysiologyGraduateStudentClimbsMt.Kilmanjaro...................................................................................................4PhysiologyDay2012.....................................................................................................................................................4PSL1048-AdvancedTopicsinPhysiology.....................................................................................................................5CongratulatonsDr.AnthonyGramolini.......................................................................................................................5ArchibaldByronMacallumLecture...............................................................................................................................6OfDolphinsSeaLionsManateesandMan-Physiologyatitsbest...........................................................................7DepartmentofPhysiology-ACampaigninSupportofResearchFacultyandStudents..............................................8RetrementsDrs.MiltonCharltonJonathanDostrovskyWilliamMacKay................................................................10On-LinePhysiologyCourse-SCS2159.........................................................................................................................13NewFacultyProles......................................................................................................................................................13InductonofDr.J.J.R.MacleodintotheCanadianHallofFame...................................................................................16Post-SurgeryMemoryLossMaybeReversible.............................................................................................................16 3AlumniNewsletterSpring2013CELEBRATING90YEARSOFINSULINNewDiscoveryofInsulinExhibitaTrueSliceofHistoryAuthorAnjumNayyarhttpnews.utoronto.cacelebrating-90-years-insulinThenewDiscoveryofInsulinexhibitfeaturingtheirbelongingsmarksthe90thanniversaryofthediscoveryofinsulin.NinetyyearsafterFrederickBantingCharlesBestJohnMacleodandBertramCollipuncoveredtheroleofinsulinindiabetesthelegacyoftheirground-breakingdiscoveryhasaplacetocallhome.AnewexhibitatMaRSDiscoverycalledInsulinTorontosGifttotheWorldletsanyonewalkthroughadayinthelifeofthediscoveryandlivesofthefamousUniversityofTorontoscientists.TheexhibitisajointeffortoftheFacultyofMedicinetheMaRSDiscoverycommercializationinitiativeandtheUniversityHealthNetworkagroupofUofTteachinghospitals.TheexhibitisframedbyBantingsdeskononesideandhislabbenchontheothersidesaidPatriciaBrubakeraprofessorintheDepartmentofPhysiologywhoworkedwithmembersoftheFacultyofMedicineahistorianandadesignteamtocreatetheexhibit.ThehistorianintheteamChrisRuttyfoundsomeoldarchivalfootageofDr.Bantingthathehaddigitized.WealsohavetheoriginalglucometerthatwasusedbyBantingandBest.IfyoulookatthedisplaythatwehaveyoucanseeareproductionofapaintingofBantingandBestworkinginthelaboratoryandprominentinthisistheglucometer.SoyoulookatthepaintingofBantingandBestworkinginthelabandthenyoulookatthelabbenchbelowthepaintingyoucanseethesameglucometeraswellasotheritemstheyhadused.TherearealsoseverallettersincludedinthedisplayfromgratefulpatientsalthoughthereisreportedlyoneadditionalletterthatisnotinthedisplaywithanenvelopethatwasaddressedtothedoctorthatdiscoveredinsulinTorontoCanadaanditmanagedtonditswaytoBantingthisreallyindicateshowwellknownDr.Bantingwasasaresultofthediscoveryofinsulin.ProfessorGaryLewisdirectoroftheBantingandBestDiabetesCentrehometoadvancingdiabetesresearchatUofTsaystheexhibitisawelcomeadditiontothecentersworkandislongoverdue.WatchCBCsvideoaboutBantingandthecreationoftheexhibitathttpwww.cbc.canewshealthstory20111027f-banting-honour.html.Brubakersaysthegoaloftheexhibitwasnotonlytocommemoratethediscoverybutalsotobeaplaceforfuturelearning.ThevisionwastobebroaderthantheUniversityofToronto.Wehopetohavehighschoolprogramscomingherebecausetheyteachthehistoryofinsulininclassrooms.DoorsOpencomestotheMaRsbuildingandinadditionforyearstheBantingandBestDiabetesCentrehasbeengettingphonecallsfrompeoplewithdiabeteswhosayweknowitwasdiscoveredherewherecanwegotoseeanydisplaysThisexhibitwillbeopenallyearlong247. AlumniNewsletterSpring20134PHYSIOLOGYGraduateStudentClimbsMt.KilmanjaroLastsummerPhysiologysgraduatestudentSeanMcFaddenMSccandidateBelshamlabclimbedMt.KilimanjarosMachemewhiskeyrouteinordertoraisemoneyforTumainiChildrensFoundationTUCHIFOorphanage.TUCHIFOisanotforprotcharitableorganizationdedicatedtothecaresupportandeducationoforphanedandneedychildreninandaroundthevillageofUsaRiverTanzania.ThisorphanageisimportanttomepersonallysaidSeanIhaveseenitgrowfromanideaintorealitywhilemyAuntandfounderCherieSzucsworkedtirelesslytondasuitablefacilitytohouseorphansandunderprivilegedchildren.In2010sheachievedamajorstepping-stonewhenTUCHIFOacquiredcharitablestatusinCanada.AfterseeingtheyearsofdedicationandthestrugglesshefacedtomakeTUCHIFOarealityIwasinspiredtohelpinanywaypossible.IapproachedmyAuntayearagowiththeideatoraisemoneyfortheorphanagebyclimbingthehighestmountaininAfricaMt.Kilimanjaroconvenientlylocatedanhoursdrivefromtheorphanage.ThisAugustIachievedthisgoalarrivingatUhurupeakjustintimetoseethesunrise.Ialsoraisednearly5000forTUCHIFOwithmyclimbingcompanions.AfterreturningfromthislifechangingadventureseeinghappyhealthychildrensavedfromalifeofmiseryandgoingtotheroofofAfricaandbackIaminspiredtosharemyexperienceswithothers.ClimbKiliForTumaini.comisawebsiteIstartedtoraisemoneywithmyfellowclimbersforTUCHIFO.IamnowchangingthefocusofthiswebsitetoaccommodateothersintheirgoaltoraisemoneyspendtimeattheTumainiorphanageclimbMt.KilimanjaroandexperienceAfrica.PHYSIOLOGYDAY2012OnApril24ththe3rdAnnualPhysiologyDaywashostedbytheDepartmentofPhysiologyincooperationwithGASPLetsTalkScienceandtheDivisionofTeachingLabs.Sixty-fourGrade11highschoolstudentsfromaroundtheGTAwereinvitedtoparticipateinavarietyoflabactivitiesandtalksrelevanttothestudyofphysiology.Anexcellentteamof12graduatestudentsfromtheDepartmentleadstudentsthroughworkshopsthatcoveredimportantconceptsrelatedtothecardiovascularsystemrespiratorysystemandDNA.Thiseventprovidedauniqueopportunityforthestudentstoreinforcetheirknowledgeinauniversitysettingaswellasachancetochatwithgraduatestudentsaboutpost-secondarylife.IwouldliketoextendmythankstoDr.MatthewsandDr.FrenchtheDivisionofTeachingLabsGASPandallvolunteersinvolvedformakingtheday-longeventagreatsuccessMichaelTian-GraduatestudentLambelabOutreachCoordinatorGASP 5AlumniNewsletterSpring2013PSL1048HAdvancedTopicsinPhysiologybyLyanneSchlichterTranslationalPhysiologyFrommoleculestomodelsystemstotheclinicThisnewgraduatecourseinPhysiologyranforthersttimeinthefallof2011.Thephilosophyunderlyingthecourseisneatlyencapsulatedbytwoquotationsfromthecommentary1thataccompaniedthe2011EdwardAdolphLectureoftheAmericanPhysiologicalSocietybyMichaelJ.Joyner2.Joynerprovocativelycontrastedtherelativefailuretodateatleastofthemolecularrevolutionofthepast30orsoyearstodeliveronitsownpromisesofcuresagainstthesuccessesofphysiology.Notjustasadisciplinethathasdeliveredhugeadvancesinunderstandingdiagnosingandtreatinghumanandotheranimaldiseasebutasthecornerstoneofwhatiscurrentlythemajorbiomedicalresearchpushtranslationalresearch.ThiscourseisdesignedforGraduatestudentsfromallsubspecialtiesinPhysiology.Thebroadgoalistodevelopanunderstandingofhowpotentialtreatmentsareidentiedandvalidatedthroughallpre-clinicalstagesincludingmolecularcell-biologyphysiologyandanimalstudies.Byanalyzinganddiscussingpublishedarticlesstudentswillfurthertheirunderstandingofidentifyingmoleculese.g.genome-widehumanscreensdiscoveringmutatedgenesdesigningapplyingcell-basedstudiese.g.selectingcreatingappropriatecell-basedassayshigh-throughputscreeningselectingcreatingappropriatemodelsattheorganoranimallevelobtainingproof-in-principledataproceedingtoclinicaltrialsAsamplingofpasttopicsFailureofanadvancedclinicaltrialWhatwentwrongCNSinammationHarmfulorhelpfulGoodfatandbadfatIdentifyingCysticFibrosistherapiesfromlargescalegenomicsandproteomicsstudiesAdditionalaimsofthecoursearetoaugmentoralandvisualpresentationskillsskillsinbothleadingandparticipatingingroupdiscussionscriticalandanalyticalthinkingawarenessoftranslationalmedicineresourcesincludingjournalslocalseminarscentresandconsortia.Eachsessionwillstrivetoincludesomecontroversy.Forexamplethepresentedpapersmightreectdifferingviewsonthemoleculeunderlyingadisorderthecellularoranimalmodelsusedortheinterpretationofgenomicstudies.1.CommentaryWagnerPDandPatersonDJ.Physiologyfoundintranslation.JApplPhysiol111333-3342011.2.TheEdwardAdolphLectureoftheAmericanPhysiologicalSocietyJoynerMJ.GiantsuckingsoundcanphysiologylltheintellectualvoidleftbythereductionistsJApplPhysiol1113353422011.CongratulationstoDr.AnthonyGramolinietal.TheirpaperentitledIdenticationofNovelRyanodineReceptor1RyR1ProteinInteractionwithCalciumHomeostasisEndoplasmicReticulumProteinCHERPwasselectedasoneof20Bestof2011byTheJournalofBiologicalChemistry.Manuscriptswereselectedfromthemorethan4000paperspublishedlastyear.Paperswerechosenfromeachofthejournalsafnitygroupsforitsexcellenceandpotentialimpactontheeld.Pleasevisithttpwww.jbc.orgsitebestoftheyeartoseeallmanuscripts.Congratulations 6AlumniNewsletterSpring2013PhysiologysAnnualArchibaldByronMacallumLectureWasheldonThursdayMay2ndintheJJRMacleodAuditoriumFacultyofMedicine.WeweredelightedtowelcomeDr.LeroyHoodPresidentInstituteforSystemsBiologySeattlewhospokeontheComplexityParadigmChangesSystemsBiologyandMedicine.ThiswasfollowedbyanAlumniReception. 7AlumniNewsletterSpring2013Iamenclosingagiftof___________________insupportofthePhysiologyAnnualFund0570047880YourgiftothePhysiologyAnnualFundwillsupportourDepartmentsmissiontoexcelinResearchandEducatonmadepayabletotheUniversityofTorontoDepartmentofPhysiologyChequeenclosedVisaMasterCardAMEXCardExpPleasesendyourdonationstotheUniversityofTorontoDonationsManagementJ.RobertS.PrichardAlumniHouse21KingsCollegeCircleTorontoOntarioM5S3J3Areceiptforincometaxpurposeswillbeissuedforalldonations.CharitableReg.BN108162330-RR0001NameoncardNameAddressCityProvincePostalCodeYOURPRIVACYTheinformationonthisformiscollectedandusedfortheadministrationoftheUniversitysadvancementactivitiesundertakenpursuanttotheUniversityofTorontoAct1971.Ifyouhaveanyquestionspleaserefertowww.utoronto.caprivacyorcontacttheUniversitysFreedomofInformationandProtectionofPrivacyCoordinatorat416946-7303McMurrichBuildingRoom20112QueensParkCrescentWestTorontoONM5S1A8.OfdolphinssealionsmanateesandmanPHYSIOLOGYatitsbestWithlogisticalassistanceprovidedbytheOceanographicEnvironmentalResearchSocietytheDepartmentofPhysiologyranitsseconduniqueandsuccessfuleldcoursePSL379livingmarinemammaleldphysiologyfromApril28toMay112012atamarinemammalfacilitylocatedinRivieraMayaanationalpreserveinMexico.Thiseldcoursegotthestudentsoutoftheclassroomandgavethemtheopportunitytoexperiencelivingphysiologywiththeseremarkablecreaturesbygettingupcloseandpersonalwithanumberofmarinemammalspecies.Dailyinwaterinteractionswithdolphinsmanateeandsealionsinacontrolledyetnaturalenvironmentallowedthestudentstoexperienceappliedphysiology.Thiswasanopportunityofalifetimeastherearefewfacilitieswherestudentscaninteractcloselywithmarinemammalsinanaturalhabitat.DrWittnichthecoursescreatorandmaininstructorsaysthiscoursebringsphysiologytolifeforuniversitystudentswhogetararechancetotouchandinteractwiththeseamazinganimalswhilelearningcomparativemarinemammalphysiologyintheeld. 8AlumniNewsletterSpring2013 9AlumniNewsletterSpring2013 10AlumniNewsletterSpring2013RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTSDr.MiltonCharltonbyDr.HaroldAtwoodMiltonCharltonsremarkablescienticcareerbeganandwillconcludeattheUniversityofTorontowithsignicantdetourstootherlocationsalongtheway.Hisinterestinphysiologyandespeciallyneurophysiologywasboostedduringhisundergraduatestudiesinthelate1960sphotographingactionpotentialsontheoscilloscopescreenandbeingabletotestphysiologicalhypothesesinrealtimewereformsofgraticationwhichMiltoncouldnotresistandhelaunchedintograduateworkatMcGillUniversityandtheUniversityofTexasinAustin.SpurredbyambitionheelectedtostudysynaptictransmissioninthegiantsynapseofthesquidforhisPhDresearch.NeitherMiltonnorhissupervisorcouldclaimanyrst-handexperiencewiththispreparationandMiltonsinitialeffortswiththeTexassquidwhichhadrathertoughsynapsesprovedfrustrating.ButintheprocessofprolongedfailuretomakemuchheadwayMiltonacquiredthenecessaryskillsandexpertisethatensuredfuturesuccess.ThiscamewhenhewasawardedasummerGrassFellowshipattheMarineBiologicalLaboratoryWoodsHole.HerehefoundthattheYankeesquidweremuchmorereceptivetohiselectrophysiologicaladvancesandhegotalltherecordsheneededforhisPhDthesisandsignicantpublicationsduringasinglesummer.AlwaysadedicatedCanadianMiltonreturnedtoTorontoonapost-doctoralfellowshipandenjoyedafruitfulperiodofexperimentationinHaroldAtwoodslaboratoryintheDepartmentofZoology.Hisexperimentsembracedseveralnewtechniquesandmaterialfrombothvertebrateandinvertebratesourceshealwaysaimedtoselectthemostappropriatepreparationstoaddresshischosenhypotheses.Atthattimethesquidgiantsynapseaffordedthebestopportunitiestoexaminetherolesofcalciumandotherionsinsynaptictransmissionandfacilitation.Miltonperseveredwiththisproblemandperfectedspecializedvoltage-clampequipmentforrapidlycontrollingmembranepotentialofthepresynapticnerveterminalandproceduresformicro-electrodeinjectionsofionsandothermaterialsintothesquidsynapse.ThischallengingworkwhichhecontinuedasafacultymemberatOhioUniversitysoonledtocollaborationsatWoodsHolewithseveraloutstandingyounginvestigatorsespeciallySteveSmithandGeorgeAugustineandtoanumberofhighlyrecognizedandhighlycitedresearchpapers.MiltonsresearchexperienceimpressedasearchcommitteeintheDepartmentofPhysiologyandledtohisreturntoTorontoin1982wherehehasservedasafacultymemberforalmostexactlythreedecades.HewastherstintheDepartmenttointroducetechniquesofoptophysiologytheuseofopticalindicatorsforsignalingtheintracellulardynamicsandlocationsofselectedionsandmoleculesinlivepreparationsespeciallycalciumionsandhetookaleadingroleinpromotinguseofnewtechniquesincludingconfocalmicroscopy.HisresearchalsocontinuedatWoodsHoleproducingadditionalhighlysignicantresearchresultsincludingtheuseofaliencalciumchelatorstoprobetheintracellularlocationsandbindingpropertiesofcalciumreceptorsforneurotransmitterrelease.SeveralotherimportantdiscoveriesandlinesofinvestigationalsoopenedupinhisTorontolaboratory---inparticulartheinteractionsbetweenterminalSchwanncellsandneuromuscularjunctionswithRichardRobitailleandothersthephysiologicalandmolecularcausesofsynapticdifferentiationandspecializationandtherolesofintracellularorganellesinsynapticfunction.Miltonhassetahighstandardofscienticintegrityinallofhisworkwhichhasstoodthetestsoftimeandrepetition.Hehasbeenacuteinhisjudgementsaboutthesignicanceofscienticproblemshehastackledadeptatforminghypothesesskillfulinselectingexperimentalmaterialtosuithishypothesesandtimeandagainhehasbeentenaciousinmasteringthetechnologyneededforsuccessfulexperimentation.Hiscareerexempliesthevalueofpersistenceinpursuitofagoodideaandtheneedtocometotermswithinitialfailureandtolearnfromit.AsafacultymemberMiltonhasalsocontributedgreatlytoteachingresearchandadministrationattheUniversityofToronto.Hehasbeencontinuouslyinterestedintheeducationandconcernsofbothgraduatestudentsandadvancedundergraduatestudentsandhasbeenabletoimparthisapproachestoscienceandlifetomanydevelopingscientists. 11AlumniNewsletterSpring2013.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTS.RETIREMENTSDr.JonathanDostrovskybyKarenDavisBarrySessleWilliamHutchisonWewouldliketoacknowledgethemanycontributionsofDr.JonathanDostrovskyontheoccasionofhisretirementfromtheDepartmentofPhysiology.Jonathanhasbeenanoutstandingleaderinhumanandanimalmotorcontrolandpainresearchpaineducationandcontributionstomanyotherlocalnationalandinternationalorganizationsforover40years.Jonathansresearchaccomplishmentsareexceptionalhavingpublishedover200high-qualitypublicationsthathavehadtremendousimpactonthefundamentalunderstandingofpainmechanismsinbothspinalandtrigeminalsensorypathways.BesidesthismainareaofinterestJonathanalsoexpandedhisresearchinteresttoincludemotorcontrolandbasalgangliaresearch.Hisanatomicalandelectrophysiologicalstudieshaveincludedgroundbreakingworkthatspanareassuchasdescendingcontrolglutamateandglialsignalingneuroplasticityandcentralsensitizationinanimalmodelsofpainthatrangefromheadachetophantompainandotherneuropathicpainstateshehasalsocontributedtoourunderstandingofprocessesunderlyingtherrmoreception.Heisalsoespeciallywellknownforhiscriticalroleinestablishingintra-operativecellularrecordingsduringneurosurgicalproceduresthatledtonumerousnoveldiscoveriesaboutthemechanismsofpainanddeepbrainstimulation.JonathanhasbeenadedicatededucatorattheUniversityofToronto.Hesupervisedmorethan45traineesmanywhohavegoneontoacademicandclinicalcareersoftheirown.Hewasdirectorforover25yearsofthetrans-universityCollaborativePrograminNeurosciencethatinvolvesacademicstaffandstudentsfromseveralFacultiesandover2dozenuniversitydepartmentsandoffersover50neurosciencegraduatecoursessomeofwhichcoveraspectsofpain.HealsowasdirectorofagraduatecourseonPainandSomatosensoryPhysiologyforover25yearsandhadotherleadershiprolesindevelopingandteachingundergraduategraduateandprofessioncoursesonpain.JonathanisalsoafoundingmemberandResearchCommitteeChairoftheUniversityofTorontoCentrefortheStudyofPainacentrethatestablishedanovelinternationallyacclaimedinter-professionalpaineducationprogramthecurriculumandeducationaloutcomespublishedinPain.JonathanhashadimpactoninspiringyoungmindsthroughhisleadershipinlocalandnationalBrainBeesforover10yearsaswellasotherpublicbrainawarenessevents.JonathanhashadtremendousnationalandinternationalimpactthroughhisserviceworktotheInternationalAssociationfortheStudyofPainIASPandmembershipintheInternationalBasalGangliaSocietyIBAGS.HechairedtheSPCofthe2002IASPWorldCongressonPainandwasco-editorofthepublishedIASPPressProceedingsofthatCongressandhealsohasservedmanyexecutiverolesintheIASPNeuropathicPainSIG.HeservedasanassociateeditorforPainfor10yearsandisnowamemberoftheFacultyof1000.HealsohasservedasPresidentoftheCanadianAssociationforNeuroscience.JonathansdistinguishedcareerhasbeenhonouredincludingreceivingtheDistinguishedCareerAwardfromtheCanadianPainSocietyin2005.Drs.WilliamHutchisonandJonathanDostrovsky 12AlumniNewsletterSpring2013OntheOccasionofDr.BillMacKaysRetrementbyHonKwanTomanyofusBillisknownasacentralgureintheteachingenterpriseofourDepartment.AlsowellknownishistextbookNeuro101arguablyoneofthemostup-to-datetextsonfundamentalneurophysiology.NotaswellknownhoweveristhatBillisaninuentialgureinCNSresearch.Over30yearsagothecerebellumaninconvenientappendagetothecerebrumwasanenduringenigmatotheneurosciencecommunity.OnthebasisofhisexperimentalworkandutterlythoroughhistoricalanalysisBillwasthersttoexplicitlyformulatethehypothesisthatthecentralroleofthecerebellumwasinthemodulationoftheresponsivenessofreexes.Withthisresponsivenesswemovewithgraceandefciency.Thisconceptualbreakthroughimmediatelytookrootandhassincebecomepivotalinanyseriousdiscussionofcerebellarfunction.Inourclimateoftoutingpapercountsandimpactfactorsastruemeasuresofresearchproductivityonetendstoneglectthelongevityandcontinuingcurrencyorthetimelessnessofaresearchworkwhichareinmanyregardsmorerelevantmeasuresofonesinuenceintheeld.TheunendingcitationofBillsbodyofworkforover30yearsuptothepresentdayisatestamenttoBillsuncommonintellect.ThisisperhapsnotsurprisinggivenBillsdistinguishedintellectuallineagethroughhissupervisorJohnMurphydirectlytoSirJohnEcclesandthencetoSirCharlesSherringtontoweringguresofmodernneuroscience.IamsureourcolleaguesintheDepartmentwilljoinmeinwishingBillamostenjoyableretirementtendinghisgardensinNewBrunswickinthespiritofthegreatVoltaire. 13AlumniNewsletterSpring2013On-LinePhysiologyCourse-SCS2159CongratulationstoDr.NohjinKeeforgracingthisyearscoveroftheUniversityofTorontoSchoolofContinuingStudiescalendar.ThePhysiologyonlinecoursetherstfullyinteractivefullcreditequivalentcourseintheFacultyofMedicineisbeingproledonthecoverpageofSchoolofContinueStudiesSCS2012-13calendar.Dr.NohjinKeethecoordinatorofthesuiteofPhysiologyonlinecourseswillalsoappearonpostersadvertisingSCSandthePhysiologycoursethroughoutToronto.TheonlinephysiologycoursewasdevelopedbytheDepartmentofPhysiologyandhasbeenofferedinpartnershipwithSCSforthepast5years.ThisinnovativeonlinecourseoffersonlinestreamingvideolecturesdevelopedbycollaborationbetweenPhysiologyandDiscoveryCommonseffectiveonlinestudentassessmentandevaluationsaccesstolecturesreal-timeaccesstovirtualTeachingAssistantofcehoursandarobustonlineplatformfordiscussion.Todatealmost600non-UofTstudentshavetakenthiscourseeithertofullltheirphysiologycourserequirementforentranceintovarioushealthscienceprogramssuchasnursingOTPTandSpeechandLanguagePathologyandDentistryfortransfercredittowardstheirdegreeprogramsprimarilyUSschoolsorjusttolearnabouthowthebodyfunctions.BasedonthegenericprototypeoftheonlinePhysiologycourseonlinebiochemistryandanatomycourseshavebeendevelopedinthepastyear.NewFacultyProfilesDr.BrianCoxIamdelightedtoannouncethatDrBrianCoxhasjoinedtheDepartmentofPhysiologyasofFebruary1st2012.Brianhasanoutstandingtrainingindevelop-mentalbiology.Hehasutilizedproteomicandgenetictechniquestoinvestigateseveralaspectsofdevelopment.MostrecentlyBrianhasundertakenimportantandhighlynovelworkinvestigatingplacentaldevelopment.Inthesestudieshehasdeterminedthecomplexproteinandgeneinteractionsthatoccuratthematernalfetalinterfaceinbothhumansandmice.ThroughthesestudiesBrianhasbeenabletoclassifyfourdistinctmolecularpathologiesofpre-eclampsiaamajorcauseofmaternalandfetaldemiseinpregnancy.Importantlythesedistinctformsofthediseasehavedifferentmetabolicandcellsignalingsignatures.HisresearchprogramintheDepartmentwillcontinuetofocusonpathologiesofpregnancyusingproteomicgeneticandepigeneticapproaches.PleasejoinmeinwelcomingBriantotheDepartmentofPhysiology. 14AlumniNewsletterSpring2013Dr.NiallFergusonDr.FergusonisAssociateProfessorofMedicineandPhysiologyattheUniversityofTorontoaScientistintheTorontoWesternResearchInstituteDirectorofCriticalCareatMountSinaiHospitalandtheUniversityHealthNetworkandtheCriticalCareLeadfortheTorontoCentralLocalHealthIntegrationNetwork.HereceivedhisM.D.withhonoursfromtheUniversityofTorontowithsubsequenttraininginInternalMedicineRespirologyCriticalCareMedicineandClinicalEpidemiology.Dr.FergusonreceivesresearchfundingfromlocalprovincialandnationalagenciesandiscurrentlysupportedbyaCIHRNewInvestigatorAward.Hiscurrentresearchinterestsinclude1mechanicalventilationepidemiologyweaningandliberationextubationandtracheostomy2acuterespiratorydistresssyndromedenitionsventilatorymanagementtrialdesignand3high-frequencyoscillatoryventilationwhereheistheco-PrincipalInvestigatorofaCIHR-fundedinternationalRCT.Dr.FergusonistheScienticProgrammeChairforCriticalCareCanadaForum.Contactn.fergusonutoronto.caDr.PatrickMcNamaraPatrickMcNamaragraduatedfromQueensUniversityBelfastin1987receivedhisMRCPCHinPediatricsin1997andCerticateofCompletionofSpecialistTraininginNeonatalMedicinein2002.HeiscurrentlyastaffneonatologistanddirectorofclinicalresearchwithintheDivisionofNeonatologyattheHospitalforSickChildrenandAssociateProfessorofPediatricsUniversityofToronto.HeisthechairoftheCanadianTargetedNeonatalEchocardiographyworkinggroupandthevice-chairoftheCanadianNeonatalResuscitationProgram.Hisclinicalandresearchinterestsincludemyocardialperformanceinthesettingsofahemodynamicallysignicantductusarteriosuspulmonaryhypertensionandneonatalcardiacarrest.Dr.WolfgangM.KueblerDr.KueblerreceivedhisMDanddoctoratedegreesDrmedsummacumlaudeattheUniversityofMunichGermanyin1997.From1997to1999heworkedasaFellowoftheGermanResearchFoundationDFGattheLungVascularBiologyLaboratoryofColumbiaUniversityJaharBhattacharya.AfterabriefreturntotheUniversityofMunichin2000wherehecompletedhishabilitationhighestacademicqualicationinGermanyin2001hejoinedtheDepartmentofPhysiologyattheFreeUniversityofBerlinnowCharitUniversittsmedizinBerlinin2002atthelevelofAssociateProfessor.In2008hejoinedSt.MichaelsHospitalwithacrossappointmentattheDepartmentofSurgeryofUofTwhilemaintainingaparttimeassociationwiththeCharitUniversittsmedizinBerlin.Dr.Kueblersresearchfocusesontranslationalresearchinpulmonaryandmicrovascularphysiologyinthatheaimstointegratebasicresearchonintra-andintercellularsignalingandcommunicationpathwaystotheleveloftheintactorganandorganism.Specicallyweapplythisapproachtotheidenticationofnewpathomechanismsandthedevelopmentofnewtherapiesforacutelunginjurylungedemaandpulmonaryhypertension.Dr.Kueblerhaspublished65originalmanuscripts12reviewsand8invitedcommentariesinpeer-reviewedinternationaljournalsaswellas3internationalpatents.Hisworkwascontinuouslyfundedbynationalandinternationalagenciessince2003.HecurrentlyservesasChairoftheRespiratorySectionoftheAmericanPhysiologicalSocietyasCo-ChairoftheAnimalCareCommitteeofSt.MichaelsHospitalandasmemberonseveralEditorialBoardsincl.AmJRespirCellMolBiolMicrocirculationandFrontiersVascBiol. 15AlumniNewsletterSpring2013Dr.AndrewRedingtonWearedelightedtowelcomeDr.AndrewRedingtontotheDepartmentofPhysiology.Dr.RedingtonholdsaprimaryappointmentintheDepartmentofPaediatricsandwillbeparticipatingintheactivitiesoftheCardiovascularandRespiratoryResearchPlatform.Dr.Redingtonsresearchinterestsincludeventricularfunctionintegratedphysiologyofcongenitalheartdiseaseandthepathophysiologyoflatepostoperativefunctionaldecline.CurrentlyheheadsaLeducqTransatlanticResearchNetworkofExcellenceinvestigatingthebiologyofremoteischemicpreconditioning.Hehaswrittenmorethan250peerreviewedpublicationsmorethan20bookchaptersandhasco-editedseventextbooks.HeistheeditorofthecongenitalheartdiseasesectionofCurrentMedicalLiteratureandservesontheeditorialboardsoftheCardiologyintheYoungandHeartandVessels.Dr.RedingtongraduatedfromtheUniversityofLondonin1981.HeobtainedhisMRCPUKinInternalMedicinein1984.In1986hewasawardedaBritishHeartFoundationResearchScholarshipandsubsequentlyreceivedhisDoctorateofMedicinein1988UK.HewasappointedConsultantPaediatricCardiologistattheRoyalBromptonHospitalLondonin1990becameafellowoftheRoyalCollegeofPhysiciansUKin1994andbecameafullprofessorintheUniversityofLondonin1995.In1998hetransferredhisclinicalpracticeandresearchteamtoGreatOrmondStreetHospitalinLondon.HemovedtoCanadainAugust2001totakethepositionofHeadofCardiologyatTheHospitalforSickChildrenToronto.Dr.Xiao-YanWenDrWensresearchfocusesonadvancedmodelsfordrugdiscovery.HerecentlyestablishedtheZebrashCentreforAdvancedDrugDiscoveryatSt.MichaelsHospital.With2MinexternalfundingtheCentrehousesCanadasrstfullyautomatedzebrashhighthroughputscreeningplatformandrepresentsamajorlargescaleinitiativeforidentifyingnovelbioactivemoleculesaffectingtissueformationandfunctioninliveanimals.UsingtheseadvancedtechnologiesandincollaborationwithmanylaboratoriesDr.WensgroupisdevelopingauniquezebrashfunctionalgenomicsprogramatSt.MichaelsHospitalandUniversityofToronto.Dr.WenobtainedhisPh.D.traininginmousetransgenicsintheDepartmentofMolecularGeneticsUniversityofTorontoandiscurrentlyaStaffScientistintheKeenanResearchCentreofLiKaShingKnowledgeInstituteatSt.MichaelsHospitalandanAssistantProfessorintheDepartmentofMedicineattheUniversityofToronto.HehasactivelyparticipatedinundergraduateteachingintheDepartmentofPhysiologysince2009teachingMammalianMolecularBiologyPSL350HandisalsodirectingagraduatecoursemoduleentitledPreclinicalAnimalModelsattheInstituteofMedicalScienceIMSUniversityofToronto.Heistherecipientofthe2005NewInvestigatorAwardfromtheCanadianSocietyofAtherosclerosisThrombosisandVascularBiologyCSATVBandthe2006CompoundValidationAwardfromtheMultipleMyelomaResearchFoundationMMRFUSA.HeisthefoundingdirectoroftheZebrashCentreforAdvancedDrugDiscovery.Contactx.wenutoronto.ca 16AlumniNewsletterSpring2013Post-surgerymemorylossmaybereversible-TeGlobeandMailPublishedMondaySeptember242012Memorylosscausedbyinammationinthebrainmaybetreatableandreversibleanewstudyhasfound.ThestudyledbyDr.BeverleyOrserstaffanesthesiologistatSunnybrookandDr.Dian-ShiWangresearchassociateintheDepartmentofPhysiologyattheUniversityofTorontofoundthatmemorylosscouldbereversedbypharmacologicallytargetingmemory-blockingreceptorsinthehippocampusapartofthebrainthatregulateslearningandmemory.InammationinthebrainhasbeenlinkedtomemorylossandcognitivedisordersincludingAlzheimersdisease.Wheninammationhasoccurredafteraninfectioninjurystrokeorevenafterasurgicalproceduretheresultingmemorylosscanbeprofoundandprolonged.Currentlythereisnotreatmentforpost-surgerymemorylosssaysDr.OrserwhoalsoworksintheDepartmentsofAnesthesiaandPhysiologyattheUniversityofToronto.Dr.OrsersteamfoundthatakeyinammatoryfactorIL-1activatesaproteinshereferstoasamemoryblockingreceptor5GABAAthegamma-aminobutyricacidAreceptoralpha5.Increasingtheactivityofthememoryblockingreceptorcausesmemorydecitsinmicehoweveroncemiceweretreatedwithadrugthatinhibitsthememoryblockingreceptormemorylosswasreversed.Theresultsofthestudyprovideinsightsintothecauseofmemorylossandapossibletreatmentassociatedwithinammationaneededeventinthehealingprocess.Althoughinammationleadstomemorylossdampeninginammationwithdrugssuchassteroidsresultsinpoorwoundhealing.WesoughttoidentifythespecicdownstreamtargetinthebrainthatcausesmemorylosswhichaccompaniedinammatoryeventssaysDr.Orser.Dr.BeverleyOrserhopesthesendingswillbeappliedtoaclinicaltrialinthenearfuturewithastudyfocusingonthosewhohaveexperiencedcognitivedecitsaftersurgery.InductonofDr.J.J.R.MacleodintotheCanadianMedicalHallofFameWearedelightedtoannouncethatDr.J.J.R.MacleodformerChairofPhysiology1918-28wasinductedintotheCanadianMedicalHallofFameonFebruary17th2012.Dr.MacleodplayedacrucialroleinthediscoveryofinsulinatUofToneofthemostimportantdiscoveriesinthehistoryofmedicine.AninternationallyrespectedresearcherincarbohydratemetabolismandphysiologyMacleoddirectedtheexperimentsthatledtoinsulinsdiscoveryanditssubsequentapplicationasaneffectivetreatmentfordiabeteswhichatthetimewasafataldisease.ForhisroleinthediscoveryofinsulintheNobelCommitteeawardedMacleodandDr.FrederickBantingthe1923NobelPrizeforMedicine.PleasevisitlinktoreadseetheentirearticlebyJimOldeldathttpnews.utoronto.cau-t-medicine-celebrates-three-inductees-canadian-medical-hall-fame.CanadianMedicalHallofFameinducteesandrepresentativesPhotocourtesyoftheHallofFame.DepartmentofMedicineProfessorEmeritusJohnDirkspicturedseatedtotherightisrenownedforhisresearchonkidneydiseaseandhisstewardshipoftheworld-renownedCanadaGairdnerInternationalAwardswhileformerprofessorDr.Lap-CheeTsuipicturedseatedtotheleftisknownforhisidenticationofthegeneforcysticbrosis.ThelateDr.JohnMacleodrepresentedbyDr.PatriciaBrubakerstandingsecondfromrightwasaleadingresearcheroncarbohydratemetabolismevenbeforehisroleindirectingtheexperimentsthatledtothecrucialdiscoveryofinsulinatUofT.